TY - JOUR AU - Kaymaz, Abdulgani AU - Ulas, Fatih AU - Erimsah, Sevilay AU - Kara Oztabag, Cansu PY - 2021/03/27 Y2 - 2024/03/28 TI - Investigation of the effect of quercetin in an experimental oxygen-induced retinopathy model JF - EXPERIMENTAL BIOMEDICAL RESEARCH JA - Exp Biomed Res VL - 4 IS - 2 SE - Articles DO - 10.30714/j-ebr.2021267976 UR - https://experimentalbiomedicalresearch.com/ojs/index.php/ebr/article/view/188 SP - 131-140 AB - <p><strong>Aim: </strong>Investigation of the effect of intraperitoneal (IP) quercetin and bevacizumab on oxygen-induced retinopathy (OIR) model in rats.</p><p><strong>Methods:</strong> In the study, 28 newborn rats were used. The OIR model was performed with the 50/10% oxygen technique. The study consisted of four groups as a control group (Group I) and OIR groups (Group II, III, and IV). IP injection applied to all groups on the postnatal day (PND) 14. Groups I and II were performed 0.9% NaCl, Group III was performed IP bevacizumab, and Group IV was performed IP quercetin. All animals were sacrificed on PND 18.</p><p><strong>Results:</strong> Based on the data obtained from immunohistochemical and histopathological examinations, the number of vascular endothelial cell (VEC), vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) levels were significantly reduced in Group III and IV compared to Group II. VECs levels were 0±0, 32.69±5.77, 2.92±0.63, and 3.64±0.36 in Group I, Group II, Group III, and Group IV, respectively <em>(p&lt;0.001)</em>. Likewise, VEGF values were 0.15±0.01, 7.57±1.80, 2.45±0.45, and 2.46±0.49, respectively <em>(p&lt;0.001)</em>. As well as TNF-α values were 0.06±0.01, 8.22±2.24, 2.32±0.32, and 2.29±0.26 in Group I, Group II, Group III, and Group IV, respectively <em>(p&lt;0.001)</em>. There was no significant difference between Group III and Group IV in terms of VEC, VEGF and TNF-α values <em>(range of p values was 0.96-1.00)</em>.</p><p><strong>Conclusion:</strong> The results of the present study showed that quercetin administration significantly reduced the VEC number and suppressed VEGF and TNF-α. Quercetin's anti-inflammatory and anti-angiogenesis effect was found to be similar to bevacizumab.</p> ER -