@article{Akkaya_Karabulut_Taskiran_2020, title={Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice}, volume={3}, url={https://experimentalbiomedicalresearch.com/ojs/index.php/ebr/article/view/100}, DOI={10.30714/j-ebr.2020361050}, abstractNote={<p><strong>Aim: </strong>To investigate whether different periods of rapid eye movement sleep deprivation (REM SD) contribute to seizure susceptibility, hippocampal oxidative status and balance of inhibition-excitation in the acute epilepsy model.</p> <p><strong>Methods:</strong> REM SD was performed using the modified multiple platforms method on adult male BALB/c mice. Pentylentetrazol (PTZ) was injected to induce seizures and hippocampal total antioxidant status (TAS), total oxidant status (TOS), <em>gamma aminobutyric acid</em> (<em>GABA</em>), and glutamate levels were measured using the ELISA method.</p> <p><strong>Results:</strong> PTZ-induced seizures following 8 h and 72 h REM SD significantly reduced the hippocampal TAS levels, but did not affect the TOS levels. In REM SD groups, especially after 8 hours of REM sleep loss, there was a significant increase in glutamate in PTZ induction. The hippocampal GABA levels were increased by PTZ-induced seizures after 72 h REM SD. PTZ- induction after 8 hours of RAM SD leads to a significant increase in the seizure duration.</p> <p><strong>Conclusion:</strong> It can be speculated that the REM SD can contribute to seizure susceptibility by changing the oxidant-antioxidant balance and excitatory and inhibitory tone in the hippocampus.</p>}, number={3}, journal={EXPERIMENTAL BIOMEDICAL RESEARCH}, author={Akkaya, Recep and Karabulut, Sebahattin and Taskiran, Ahmet Sevki}, year={2020}, month={Jun.}, pages={149–156} }