The effect of COVID-19 infection on retinal nerve fiber layer and ganglion cell complex layer thicknesses

  • Sedat Ozmen Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey http://orcid.org/0000-0002-6675-7132
  • Burcin Cakır Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey http://orcid.org/0000-0001-7816-0627
  • Huseyin Dogus Okan Department of Infection Diseases Sakarya University Medical Education and Researh Hospital, Sakarya, Turkey http://orcid.org/0000-0001-6729-8938
  • Nilgun Ozkan Aksoy Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey http://orcid.org/0000-0003-1107-9546
  • Ertugrul Guclu Department of Infection Diseases Sakarya University Medical Education and Researh Hospital, Sakarya, Turkey http://orcid.org/0000-0003-2860-2831
Keywords: COVID-19 infection, retinal nerve fiber layer thickness, ganglion cell- internal plexiform layer thickness, optical coherence tomography

Abstract

Aim:  To evaluate the possible effects of SARS-CoV-2 infection on retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GC-IPL) thicknesses.

Method: Patients who had been infected by SARS-CoV-2 and hospitalized because of severe pneumonia were found out from the database of COVID-19 pandemic hospital and formed the patient group. The control group was composed of non-COVID-19 age-matched subjects. The mean and fragmented RNFL and GC-IPL thicknesses were measured by optical coherence tomography (OCT), and compared between two groups, statistically.

Results: Patient group 34 eyes of 34 subjects (18 male, 16 female) and 31 eyes of 31 subjects (14 male, 17 female) in the control group were enrolled. The mean age and gender were not statistically different between groups (p:0.56, 0,57, respectively).A statistically significant difference was not found between groups in terms of mean, superior, inferior, temporal, nasal RNFL thicknesses and mean superior, inferior, temporal, and nasal GC-IPL thicknesses.

Conclusion: The mean and fragmented RNFL and GC-IPL thicknesses measured by OCT were not statistically different in patients who had moderate disease course and recovered from COVID-19 infection.

Published
2021-06-27
How to Cite
Ozmen, S., Cakır, B., Okan, H. D., Aksoy, N. O., & Guclu, E. (2021, June 27). The effect of COVID-19 infection on retinal nerve fiber layer and ganglion cell complex layer thicknesses. EXPERIMENTAL BIOMEDICAL RESEARCH, 4(3), 175-180. https://doi.org/https://doi.org/10.30714/j-ebr.2021370071