Could triglyceride to high density lipoprotein-cholesterol ratio predict hepatosteatosis?

  • Ozge Kurtkulagi Department of Internal Medicine, Bolu Abant Izzet Baysal University, School of Medicine, Bolu, Turkey http://orcid.org/0000-0002-4162-5563
  • Satilmis Bilgin Department of Internal Medicine, Bolu Abant Izzet Baysal University, School of Medicine, Bolu, Turkey http://orcid.org/0000-0003-2811-0052
  • Gizem Bakir Kahveci Department of Internal Medicine, Bolu Abant Izzet Baysal University, School of Medicine, Bolu, Turkey http://orcid.org/0000-0003-4520-4085
  • Burcin Meryem Atak Tel Department of Internal Medicine, Bolu Abant Izzet Baysal University, School of Medicine, Bolu, Turkey http://orcid.org/0000-0003-4201-9757
  • Mehmet Ali Kosekli Department of Internal Medicine and Gastroenterology, Bolu Abant Izzet Baysal University, School of Medicine, Bolu, Turkey http://orcid.org/0000-0002-3172-8200
Keywords: Liver steatosis, hepatosteatosis, inflammation, triglyceride, HDL cholesterol

Abstract

Aim: The triglyceride / HDL cholesterol (TG/HDL-c) ratio is increased in a variety of diseases including, coronary heart disease and type 2 diabetes mellitus. However, its role in non-alcoholic hepatosteatosis is not well understood. In present study, we aimed to compare the TG/HDL-c levels of the patients with non-alcoholic hepatosteatosis to those of the healthy subjects.

Methods: Medical data of the patients with non-alcoholic hepatosteatosis whom presented to the outpatient internal medicine clinics of our institution were retrospectively analyzed. Healthy subjects whom admissions to our clinics were due to check up were enrolled to the study as control group. TG/HDL-c of the groups compared.

Results: TG/HDL-c level of the liver steatosis group (5 (2-22) %) was higher than the control group (2.7 (1-8) %), (p<0.001). TG/HDL-c was significantly and positively correlated with fasting blood glucose (r=0.31, p<0.001), C - reactive protein (r=0.25, p<0.001) and LDL-cholesterol (r=0.3, p<0.001) levels. A TG/HDL-c value greater than 3.1% has 91% sensitivity and 77% specificity in detecting hepatosteatosis.

Conclusions: We suggest that TG/HDL-c ratio could be a useful marker of non-alcoholic hepatosteatosis due to its inexpensive and easy to assess nature.

Published
2021-06-27
How to Cite
Kurtkulagi, O., Bilgin, S., Bakir Kahveci, G., Atak Tel, B. M., & Kosekli, M. A. (2021, June 27). Could triglyceride to high density lipoprotein-cholesterol ratio predict hepatosteatosis?. EXPERIMENTAL BIOMEDICAL RESEARCH, 4(3), 224-229. https://doi.org/https://doi.org/10.30714/j-ebr.2021370081