Evaluation of epicardial fat tissue thickness in patients with multiple sclerosis

Keywords: Multiple sclerosis, epicardial fat tissue, cardiovascular diseases, inflammation, biomarkers


Aim: Multiple sclerosis (MS), which is inflammatory in its pathogenesis, damages the myelin sheath in the central nervous system (CNS) and causes axonal loss. Epicardial fat tissue (EFT), located between the myocardium and the visceral layer of the pericardium, surrounds the heart and several inflammatory cytokines is secreted from this tissue. In this study, we aimed to investigate EFT thickness in MS patients and compared with that of volunteer non-MS subjects.

Methods: A total of 154 subjects comprising 61 MS patients and 93 volunteers matched for gender and age were included in our study.  Epicardial fat tissue thickness was measured by echocardiography. All values were compared between groups.

Results: Echocardiographic parameters were similar in both groups. However, the mean EFT thickness was significantly higher in the MS group than in the control group (p<0.001). Epicardial fat tissue thickness was also significantly correlated with the presence of MS (r=0.33, p<0.001).

Conclusion: The results of our study suggest that the increase in epicardial adipose tissue thickness in MS patients may be a predictive factor for cardiovascular disease. However, the clinical significance of this finding and its relevance to MS pathogenesis should be investigated in further studies.

How to Cite
Cosgun, M., Sincer, I., Gunes, Y., Kok, Z., & Aydın Turkoglu, S. (2020, December 28). Evaluation of epicardial fat tissue thickness in patients with multiple sclerosis. EXPERIMENTAL BIOMEDICAL RESEARCH, 4(1), 58-64. https://doi.org/https://doi.org/10.30714/j-ebr.2021165782