The association of serological tests and anemia in celiac disease


  • Mervan Bekdas Dept. of Pediatrics, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey
  • Fatih Unal Dept. of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Dortcelik State Children's Hospital, Bursa, Turkey



Celiac disease, serological tests, anemia, child


Aim: Celiac disease (CD) is a common immune-mediated enteropathy caused by gluten. These patients may apply with many different clinical forms. The aim of this study is to determine the association of serological tests and type of anemia in CD.

Methods: Totally117 biopsy proven CD patients aged between 1-17 years were included. Serological and hematological parameters of all patients were studied.

Results: Anemia was identified in 71 (60.7%) cases. Patients with anemia were diagnosed earlier than other patients (5.2±4.5 vs. 15.3±33.8 years, p=0.012). Among CD patients with anemia 39 (54.9%) were having iron deficiency, 22 (30.9%) were having folate deficiency and 10 (14%) were having vitamin B 12 deficiency. In patients with tissue transglutaminase (tTG) seropositivity serum iron levels and ferritin levels were significantly lower compared to anti-gliadin antibody (AGA) or anti-endomysium antibody (EMA) seropositivity  (35±23.5 vs. 57.5±33.3, p=0.007 and 12.4±21.9 vs. 24.2±18.5, p=0.026, respectively). Low serum folate levels were more frequent in the presence of tTG seropositivity compared with AGA+EMA seropositivity (81.8% vs. 25%, p=0.015). 

Conclusions: Anemia is an important cause of admission in CD. These patients are diagnosed earlier as a result of anemia. Alone tTG seropositivity is more valuable to demonstrate anemia associated with iron or folate deficiencies.




How to Cite

Bekdas, M., & Unal, F. (2018). The association of serological tests and anemia in celiac disease. EXPERIMENTAL BIOMEDICAL RESEARCH, 1(2), 37–45.