Evaluation of newborns with vitamin D deficiency: A single-center experience

Authors

  • Seda Aydogan Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-6144-4225
  • Nurdan Dinlen Fettah Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0001-7530-1172
  • Cem Geyik Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-9944-8512
  • Elif Ozyazici Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-3801-522X
  • Hasan Akduman Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-3101-1496
  • Basak Kaya Gursoy Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-8364-1174
  • Ahmet Ozyazici Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-1389-7799
  • Dilek Dilli Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0003-2634-2562
  • Aysegul Zenciroglu Department of Neonatology, Health Science University, Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Türkiye http://orcid.org/0000-0002-3488-4962

DOI:

https://doi.org/10.30714/j-ebr.2023.187

Keywords:

Newborn, hypocalcemia, pregnancy, vitamin D

Abstract

Aim: To evaluate the demographic, clinical, and laboratory characteristics (primarily phosphorus, calcium (Ca), and alkaline phosphatase (ALP) levels of newborns with low 25-OHD levels.

Methods: In this retrospective study, babies whose 25-OHD levels were determined during hospitalization were evaluated. The newborns were classified as stated by their serum 25-OHD levels as follows: severely deficient, <5 ng/mL (group 1); deficient, 5–20 ng/mL (group 2); and insufficient, 20 to 30 ng/mL (group 3). In addition to the newborns' serum 25-OHD levels, their serum Ca, phosphorus, parathormone (PTH), and alkaline phosphatase levels and their mothers' 25-OHD levels were also measured.

Results: A total of 568 newborns were included. Serum 25-OHD level was severely deficient in 112 patients (19.7%). The mothers of the babies in group 1 were younger than those of the babies in the other groups. First PTH level (F3,1, p = 0.04) and maternal ALP level were highest in group 1. In all the groups, the maternal 25-OHD level was <30 ng/mL. Vitamin D supplementation rate during pregnancy was found to be significantly lower in the severely deficient and deficient groups than in the insufficient group (F1,84, p = 0.01).

Conclusion: 25-OHD deficiency continues to be a problem among pregnant women and their babies in Turkey despite the introduction of a supplementation program. This study emphasizes the need to improve maternal 25-OHD status to support maternal and infant health.

 

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Published

2023-07-01

How to Cite

Aydogan, S., Dinlen Fettah, N., Geyik, C., Ozyazici, E., Akduman, H., Kaya Gursoy, B., … Zenciroglu, A. (2023). Evaluation of newborns with vitamin D deficiency: A single-center experience. EXPERIMENTAL BIOMEDICAL RESEARCH, 6(3), 230–237. https://doi.org/10.30714/j-ebr.2023.187

Issue

Vol. 6 No. 3 (2023): Experimental Biomedical Research

Section

Articles

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