The relationship of monocyte to high density lipoprotein-cholesterol ratio and complete blood count parameters with radiologic staging of knee osteoarthritis

Abstract

Aim: To evaluate the predictive ability of bioindicators derived from complete blood count (CBC) parameters and monocyte-high density lipoprotein-cholesterol ratio (MHR) in the diagnosis of radiological stage of knee osteoarthritis (OA) in this study.

Method: This cross-sectional retrospective study was carried out between November 2017 and June 2021, in our physical therapy and rehabilitation clinics.  65 patients knee x-rays and routine laboratory results were included in the study. Each knee x-rays were assigned a grade from 0 to 4 (Kellgren-Lawrence Classification System (KL). Patients were divided into two groups according to severity of the knee OA as follows. Group 1: Mild-moderate OA (KL Grade1-2), Group 2: Severe OA (KL Grade 3-4).
Results: Independent T test and Mann Whitney U test were used to assess whether there was a difference in CBC parameters and their derivatives between two groups. Platelet lymphocyte ratio (PLR), red cell distribution width (RDW) to platelet ratio (RPR) and platelet (PLT) counts indicated statistically significant differences between the groups, p-values were 0.04, 0.03 and 0.04 respectively. There were no significant differences in terms of MHR score between the groups.

Conclusions: We could not find a relationship between MHR and radiological degree of knee osteoarthritis. However, there is a correlation between radiological stage of knee osteoarthritis and hemogram parameters like PLT and their derivatives such as PLR and RPR.