Does mean platelet volume and neutrophil to lymphocyte ratio increase in primary hyperparathyroidism arising from a single adenoma

Abstract

Aim: Primary hyperparathyroidism (PHP) is commonly caused by adenomas. Studies have shown mild inflammation in PHP and elevated levels of some inflammatory markers to support this. In addition, excess parathyroid hormone (PTH) and calcium (Ca) cause atherosclerosis by disrupting endothelial function. Mean platelet volume (MPV) describes the size and indirect activity of platelets and its value is expected to increase with inflammation and associated atherosclerosis. Neutrophil to lymphocyte ratio (NLR) is another parameter associated with inflammatory response. This study was performed to investigate the MPV and NLR levels in PHP developing from a single parathyroid adenoma.

Method: Patient records from 2016-2021 were retrospectively scanned from the computer system and 40 patients with PHP developing from a single parathyroid adenoma were selected based on exclusion criteria. The values of PTH, Ca, 25-Hydroxyvitamin D, phosphorus, MPV and number of blood cells were recorded. NLR was calculated. The results were compared with the results of 36 healthy controls.

Results: MPV (8.7±0.6 fl and 7.6±0.6 fl, respectively; p=0.001) and NLR (2.6±1.7 and 1.7±0.8, respectively; p=0.000) were higher in the PHP group compared to the control group. Ca and PTH correlated positively with MPV (p=0.003 and p=0.000, respectively) and NLR (p=0.011 and p=0.023, respectively).

Conclusion: MPV and NLR were found to be higher in patients with PHP developing from a single adenoma than in healthy individuals.