Early graft survival after renal transplantation, single center experience

  • Ozlem Beyler Department of Internal Medicine, Hematology and Nephrology, Ufuk University, Faculty of Medicine, Ankara, Turkey http://orcid.org/0000-0002-2032-8877
  • Mehmet Ozen Department of Internal Medicine, Hematology and Nephrology, Ufuk University, Faculty of Medicine, Ankara, Turkey http://orcid.org/0000-0002-0910-9307
  • Ihsan Ergun Department of Internal Medicine, Hematology and Nephrology, Ufuk University, Faculty of Medicine, Ankara, Turkey http://orcid.org/0000-0003-2066-5512
Keywords: Renal transplantation, acute rejection, graft survival, graft failure

Abstract

Aim: The best treatment for patient with end stage kidney disease is kidney transplantation which improve their quality of life and survival rate. The aim of our study is to determine the factors that affect the results of early outcomes of graft function.

Method: Twenty-eight adult patients who underwent renal transplantation from 2016 to 2017 were included in our university.

Results: The median age of the recipients was 38.5 (range: 19-65) and 68% (19 patients) were male. Acute rejection was detected in 8 patients. Patients who developed rejection were found to have higher panel reactive antibody positivity and higher parathyroid hormone levels. Panel reactive antibody positivity was found to be 25% in patients who developed rejection and 0% in patients who did not develop rejection (p = 0.02). The parathyroid hormone level was calculated as 963.2 ± 587 in the rejection group and 378 ± 227 in the rejection group (p = 0.003). It was observed that 37.5% of DM patients had rejection and 10% in non-diabetic patients. The difference was statistically significant (p = 0.08).

Conclusion: Panel reactive antibody positivity and parathyroid hormone levels increased the likelihood of rejection. The effect of the presence of diabetes mellitus in the patient on the development of rejection was observed to be limited. Our findings were consistent with the literature. Because of the number of patients and the short follow-up period, further studies are needed.

Published
2020-03-02
How to Cite
Beyler, O., Ozen, M., & Ergun, I. (2020, March 2). Early graft survival after renal transplantation, single center experience. EXPERIMENTAL BIOMEDICAL RESEARCH, 3(2), 71-78. https://doi.org/https://doi.org/10.30714/j-ebr.2020258646