Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism?

  • Arzu Guler Karakuz Dept. of Gynecology and Obstetrics, Bolu Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey http://orcid.org/0000-0002-8789-5761
  • Mustafa Ayhan Ekici 1Dept. of Gynecology and Obstetrics, Bolu Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey http://orcid.org/0000-0002-0745-0907
  • Mehmet Ata Topcuoglu Dept. of Gynecology and Obstetrics, Bolu Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey http://orcid.org/0000-0002-8929-6973
  • Selma Duzenli Dept. of Genetic, Bolu Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey http://orcid.org/0000-0001-9589-4091
  • Cansu Kara Oztabag Institute of Health Sciences, Doctorate in Neuroscience, Bolu Abant Izzet Baysal University, Bolu, Turkey http://orcid.org/0000-0003-2108-2458
Keywords: Polycystic ovary syndrome, FABP1 gene polymorphism, rs2197076 polymorphism

Abstract

Aim: Polycystic ovary syndrome (PCOS) is a multifactorial, endocrine, and metabolic disorder seen in 10%-20% of women of reproductive age. Due to the close relationship observed between the increased risk of type 2 diabetes and insulin resistance and the polymorphism of the fatty acid binding protein 1 (FABP1) gene rs2197076 single nucleotide polymorphism (SNP), we investigated the frequency of the FABP1 gene rs2197076 SNP in patients with PCOS.

Methods: This is a prospective case-control study. The study included 151 women—75 patients with PCOS and 76 healthy women. A real-time polymerase chain reaction was performed for the FABP1 rs2197076 polymorphism. Additionally, biochemical and hormonal levels of the patients were studied.

Results: Menstrual irregularities, the body mass index (BMI), hirsutism scores, the luteinizing hormone / follicular stimulating hormone ratio, dehydroepiandrosterone sulfate and testosterone levels were significantly higher in the PCOS group than in the control. There was no significant difference between the PCOS and control groups in terms of FABP1 rs2197076 genotype distribution and FABP1 rs2197076 allele frequency distribution.

Conclusion: There was no increase in the genotype distribution and allelic frequency of the FABP1 gene rs2197076 SNP in PCOS patients. Further studies are needed on this subject.

Published
2018-12-28
How to Cite
Karakuz, A., Ekici, M., Topcuoglu, M., Duzenli, S., & Oztabag, C. (2018, December 28). Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism?. EXPERIMENTAL BIOMEDICAL RESEARCH, 2(1), 29-36. https://doi.org/https://doi.org/10.30714/j-ebr.2019147581