G1733A (RS6152) polymorphism of the androgen receptor gene in patients with prostate cancer

  • Omer Faruk Yagli Department of Urology, Tuzla State Hospital, İstanbul, Turkey
  • Serkan Ozcan Department of Urology, İzmir Katip Çelebi University, İzmir, Turkey
  • Tolga Karakan Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey
  • Ali Osman Arslan Department of Medical Biology and Genetic, Bolu Abant İzzet Baysal University, Bolu, Turkey
  • Ali Akkoc Department of Urology, Alanya Alaaddin Keykubat University, Antalya, Turkey
  • Selma Duzenli Department of Medical Biology and Genetic, Bolu Abant İzzet Baysal University, Bolu, Turkey
  • Ahmet Metin Department of Urology, Bolu Abant İzzet Baysal University, Bolu, Turkey
Keywords: Prostate cancer; androgen receptor gene; AR gene; G1733A (rs6152) polymorphism.

Abstract

Aim: The causes of prostate cancer development and molecular mechanism underlying its development and progression are not clearly understood. The aim of this study is to determine the frequency of G1733A (rs6152) polymorphism of the androgen receptor (AR) gene among patients with prostate cancer, and to examine the role of this polymorphism in the development of prostate cancer.

Method: DNA samples isolated from 96 individuals (49 patients with prostate cancer and 47 controls) were analyzed with real time-polymerase chain reaction (real time-PCR) in order to determine G1733A (rs6152) polymorphism genotypes and allele frequencies in the AR gene. The results were evaluated statistically.

Results: Genotype frequency was determined as 91% GG and 9% AG among the controls, and 67% GG and 33% AG among the patients. G allele frequency was 95% in controls and 83% in patients, whereas A allele frequency was 5% in controls and 17% in patients. There was a statistically significant difference between patient and control groups regarding genotype frequency (p<0.05).

Conclusion: Based on the results of our study, we can infer that G1733A (rs6152) polymorphism of the AR gene plays a role in development of prostate cancer in the Turkish population.

Published
2018-09-24