Evaluation of retinal nerve fiber layer and ganglion cell layer thicknesses with optical coherence tomography in patients with vitamin B12 deficiency

  • Umit Dogan Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
  • Sule Aydın Turkoglu Department of Neurology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
  • Fatih Ulas Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
  • Adem Soydan Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
  • Abdulgani Kaymaz Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
  • Tarik Eroglu Department of Neurology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
  • Sumeyra Agca Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
Keywords: Ganglion cell layer, optical coherence tomography, retinal nerve fiber layer, vitamin B12 deficiency

Abstract

Aim: We aimed to compare the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness of B12 vitamin deficiency patients with healthy controls using optical coherence tomography (OCT).

Methods: Forty-six patients (27 females / 19 males) diagnosed with B12 vitamin deficiency and 46 healthy controls (26 females / 20 males) with similar age and sex were included in the study. RNFL thickness of global, superotemporal, temporal, inferotemporal, superonasal, nasal and inferonasal sectors and GCL thickness and volume measurements of central, superior, inferior, temporal, and nasal sectors were performed using Spectralis-OCT device in all cases.

Results: The mean age of the patient group was 42.17±15.34 years, while that of the control group was 44.21±12.34 years (p=0.528). Mean serum vitamin B12 levels were measured as 163,47±19,80 pg/ml in the patient group and 311,80±76,30 pg/ml in the control group (p <0,01). There was no statistically significant difference between the global RNFL thicknesses of the two groups (p> 0,05). However, statistically non-significant thinning was observed in the superotemporal and global RNFL thickness of the group with B12 vitamin deficiency (p values are 0,140 and 0,171, respectively). There was also no statistically significant difference between GCL thicknesses and volumes of the two groups (p> 0.05).

Conclusions: No significant reduction was observed in RNFL and GCL thicknesses of adult subjects with B12 vitamin deficiency compared with healthy controls.

Published
2018-05-07