The role of lymphocyte-monocyte ratio and platelet to lymphocyte ratio in predicting risk groups in gastrointestinal stromal tumors
Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Armed Forces Institute of Pathology (AFIP) criteria which is the basis of our study, is also known as Miettinen’s criterion is used in classification of GIST. Lymphocyte-monocyte ratio (LMR), and platelet lymphocyte ratio (PLR) have been shown as novel markers in chronic systemic inflammatory response, therefore, we aimed to study LMR levels of the subjects with moderate to high risk GIST and to compare to those in the subjects with low or very low risk GIST.
Methods: Thirty GIST patients who underwent surgery were retrospectively evaluated. Patients were divided into two groups according to the AFIP risk scoring system: the first group (group 1) included very low and low risk patients and the second group (group 2) included moderate and high risk patients. Inflammatory indicators; LMR and PLR of the groups were compared.
Results: LMR value was higher in Group 1 (5.25 ± 2.55) than the LMR of group 2 (2.92 ± 1.76). PLR value was significantly lower in group 1 (139.68) compared to the PLR of group 2 (185.04).
Conclusion: We think that LMR is effective in identifying low and very low risk patients compared to AFIP. From this point of view, we suggest that LMR can identify high and medium risk patients by excluding low and very low risk patients and may be an independent risk factor in GIST scoring systems.
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Experimental Biomedical Research journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.